סמינר בכימיה אורגנית: Cucurbit(n)uril Molecular Containers: Mechanism, Recognition Properties and Function
Prof. Lyle Isaacs, University of Maryland
Abstract:
In this talk I will present our work on the preparation and use of macrocyclic and acyclic CB[n] (left) in biologically relevant applications. For example, I will discuss the use of acyclic CB[n] as a solubilizing excipient for insoluble drugs,[1] as a reversal agent for neuromuscular block as well as hyperlocomotion induced by drugs of abuse (e.g. methamphetamine),[2] and our recent discovery of ultrahigh affinity sulfated pillararenes (right) and their applications.[3]
References:
[1] G. Hettiarachchi, S. K. Samanta, S. Falcinelli, B. Zhang, L. Isaacs, V. Briken, Mol. Pharmaceut. 2016, 13, 809-818.
[2] S. Ganapati, P. Y. Zavalij, M. Eikermann, L. Isaacs, Org. Biomol. Chem. 2016, 14, 1277-1287. S. Ganapati, S. D. Grabitz, S. Murkli, F. Scheffenbichler, M. I. Rudolph, P. Y. Zavalij, M. Eikermann, L. Isaacs, ChemBioChem 2017, 18, 1583-1588
[3] W. Xue, P. Y. Zavalij, L. Isaacs, Angew. Chem. Int. Ed. 2020, 59, 13313-13319.
